Mesenchymal stem cell-derived lncRNAs NKILA contributes to stemness and chemoresistance by fatty acid oxidation in gastric cancer via miR-485-5p/STAT3

Figure 4 NKILA promotes fatty acid oxidation of gastric cancer cells by STAT3. The MKN45 and AGS cells were transfected NKILA and co-treated with STAT3 shRNA of ETX. A: The expression of STAT3 was measured by qPCR; B: The CPT1 activity was detected in the cells; C: The β-oxidation was analyzed in the cells; D: The relative ATP levels was determined in the cells; E: The mRNA expression of SOX2, Oct4, LIN28, and CD133 was measured by qPCR; F and G: The chemoresistance of oxaliplatin or 5-Fu was detected by CCK-8. ^aP < 0.01.