Oxocrebanine inhibits the proliferation of hepatocellular carcinoma cells by promoting apoptosis and autophagy

Figure 7 Inhibitory effect of oxocrebanine on growth of Hep3B2. 1-7 cells in vivo. Hep3B2.1-7 cells were injected into the right flanks of Nu/Nu mice (5 mice/group). When tumor volumes reached 50 mm³, mice were treated with indicated formulations every 3 days for 5 times. A: Tumor mass images of Hep3B2.1-7 model mice at day 18; B: Tumor volumes at different time points; C: Apoptosis and LC3 expression in tumor xenografts detected by TUNEL and IHC, respectively; D: Survival curve. Data are shown as the mean ± SD; ^aP < 0.05 vs control; ^bP < 0.01 vs control.