Circular RNA hsa_circRNA_101996 modulates gastric cancer cell proliferation and apoptosis through the miR-577/HMGN5 axis

Figure 3 Validation of the regulatory relationship among hsa_circRNA_101996 and miR-577. A: CircInteractome was used to predict the binding site of circRNA_101996 and miR-577; B: The expression of miR-577; C and D: Luciferase reporter gene assays confirmed the target relationship between hsa_circRNA_101996 and miR-577 in OCUM-1 and HSC-39 cell lines; F: The expression of miR-577; G: Compared with the adjacent tissues, miR-577 expression was notably downregulated in gastric cancer tissues. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001. NC: Negative control.