Circular RNA hsa_circRNA_101996 modulates gastric cancer cell proliferation and apoptosis through the miR-577/HMGN5 axis

doi:10.4251/wjgo.v17.i5.105933

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May 15, 2025 (publication date) through Jun 8, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. May 15, 2025; 17(5): 105933
Published online May 15, 2025. doi: 10.4251/wjgo.v17.i5.105933

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Figure 2 Hsa_circRNA_101996 promotes gastric cancer proliferation and suppresses apoptosis. A and B: The efficiency of circRNA_101996 knockdown and overexpression in the OCUM-1 and HSC-39 cell lines; C and D: MTT assay in OCUM-1 and HSC-39 cell lines; E: Colony formation assay in OCUM-1 and HSC-39 cell lines; F: The Bcl-2/Bax ratio was significantly decreased in OCUM-1 and HSC-39 cells of the shCircRNA_101996 group, while the Bcl-2/Bax ratio was significantly increased in cells of the pLV-CircRNA_101996 group. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001. NC: Negative control.

Citation: Wang XL, Zhang L, Shang Q. Circular RNA hsa_circRNA_101996 modulates gastric cancer cell proliferation and apoptosis through the miR-577/HMGN5 axis. World J Gastrointest Oncol 2025; 17(5): 105933
URL: https://www.wjgnet.com/1948-5204/full/v17/i5/105933.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i5.105933