Integrating ultrasound and serum indicators for evaluating outcomes of targeted immunotherapy in advanced liver cancer

Table 5 Comparison of net reclassification index and integrated discrimination improvement between the Target Immunotherapy Predictive Model and other classical models

Model	Internal training cohort, NRI	Internal training cohort, IDI	Internal validation cohort, NRI	Internal validation cohort, IDI	External validation cohort, NRI	External validation cohort, IDI
TIPM vs TNM	0.175	0.374	0.258	0.481	0.418	0.435
TIPM vs BCLC	0.330	0.497	0.238	0.330	0.605	0.492
TIPM vs CNLC	0.387	0.423	0.440	0.587	0.534	0.355
TIPM vs HKLC	0.278	0.385	0.602	0.558	0.754	0.454
TIPM vs CRAFITY	0.225	0.340	0.329	0.451	0.484	0.401

NRI: Net reclassification index; IDI: Integrated discrimination improvement; TIPM: Target Immunotherapy Predictive Model; TNM: Tumor-node-metastasis; BCLC: Barcelona Clinic Liver Cancer; CNLC: China Liver Cancer; HKLC: Hong Kong Liver Cancer; CRAFITY: C-reactive protein and alpha-fetoprotein in immunotherapy.