Combined detection of P53, Ki67, P504S, and IMP3: Diagnostic implications for gastric cancer and precursor lesions

doi:10.4251/wjgo.v17.i5.105604

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World Journal of Gastrointestinal Oncology

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1948-5204

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World J Gastrointest Oncol. May 15, 2025; 17(5): 105604
Published online May 15, 2025. doi: 10.4251/wjgo.v17.i5.105604

Table 2 Sensitivity and specificity of P504S, Ki67, and their combination for diagnosing low-grade dysplasia

	Group		Sensitivity	Specificity
	Others¹	LGD	Sensitivity	Specificity
P504S			53.33%	75.48%
-	117	14
+	38	16
Ki67			76.67%	95.48%
Others (-)	148	7
Polarity (+)	7	23
Combination of P504S and Ki67²			90.00%	73.55%
-	114	3
+	41	27

¹Others include atypical hyperplasia, high-grade dysplasia, and adenocarcinoma.

²P504S and Ki67 are used in parallel for the combined diagnosis of low-grade dysplasia.

LGD: Low-grade dysplasia.

Citation: Miao LF, Sun YY, Du XJ, Xu N, Shen JW, Hua H, Guo M, Yang HJ, Li JK, Zhu L. Combined detection of P53, Ki67, P504S, and IMP3: Diagnostic implications for gastric cancer and precursor lesions. World J Gastrointest Oncol 2025; 17(5): 105604
URL: https://www.wjgnet.com/1948-5204/full/v17/i5/105604.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i5.105604