Diagnostic value of alpha-fetoprotein and prothrombin induced by vitamin K absence-II in serum, bile, and feces in hepatocellular carcinoma

Table 2 Analysis of the diagnostic efficacy of alpha-fetoprotein and prothrombin induced by vitamin K absence-II in serum alpha-fetoprotein or prothrombin induced by vitamin K absence-II negative group

Group	Indicators	Sensitivity (%)	AUC (95%CI)	P value
Serum AFP negative group	Serum PIVKA-II	75.3	0.887 (0.827-0.947)	< 0.001
	Bile AFP	13.9	0.657 (0.487-0.828)	0.079
	Bile PIVKA-II	38.9	0.537 (0.369-0.705)	0.679
	Fecal AFP	0.0	0.512 (0.347-0.649)	0.868
	Fecal PIVKA-II	4.3	0.386 (0.250-0.521)	0.105
Serum PIVKA-II negative group	Serum AFP	61.2	0.848 (0.765-0.931)	< 0.001
	Bile AFP	55.0	0.842 (0.714-0.969)	0.001
	Bile PIVKA-II	5.0	0.270 (0.088-0.452)	0.021
	Fecal AFP	6.0	0.561 (0.415-0.708)	0.418
	Fecal PIVKA-II	6.0	0.352 (0.214-0.491)	0.051
Both serum AFP and serum PIVKA-II negative group	Bile AFP	0.0	0.648 (0.426-0.871)	0.233
	Bile PIVKA-II	11.1	0.230 (0.018-0.441)	0.030
	Fecal AFP	18.2	0.483 (0.274-0.692)	0.872
	Fecal PIVKA-II	9.0	0.414 (0.209-0.619)	0.412

AFP: Alpha-fetoprotein; AUC: Area under the curve; CI: Confidence interval; PIVKA-II: Prothrombin induced by vitamin K absence-II.