Validation and analysis of key factors of Banxia Xiexin decoction against gastric cancer

doi:10.4251/wjgo.v17.i5.104737

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May 15, 2025 (publication date) through Jun 17, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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World J Gastrointest Oncol. May 15, 2025; 17(5): 104737
Published online May 15, 2025. doi: 10.4251/wjgo.v17.i5.104737

Table 4 Comparison of relative expression of phosphatidylinositol 3-kinase/AKT signaling pathway mRNA in each group

Group	*PIK3CA*	*HSP90AA1*	*PIK3R1*	*AKT1*	*TP53*
GES-1	1.00 ± 0.00	1.00 ± 0.00	1.00 ± 0.00	1.00 ± 0.00	1.00 ± 0.00
AGS	1.97 ± 0.011^b	3.73 ± 0.86^a	5.75 ± 0.77^b	1.86 ± 0.09^b	4.66 ± 2.11^a
Capecitabine	0.44 ± 0.05^d	1.26 ± 0.11	2.81 ± 1.41	0.47 ± 015^d	0.13 ± 0.01^c
BXD	0.85 ± 0.09^c	1.34 ± 0.19	0.55 ± 0.31^c	0.91 ± 0.20^d	0.21 ± 0.09^c
LY294002	1.61 ± 0.22	2.01 ± 0.55	0.52 ± 0.08^d	0.84 ± 0.03^d	0.27 ± 0.16^c
BXD + LY	0.14 ± 0.11^d	1.11 ± 0.05	0.46 ± 0.35^d	0.88 ± 0.17^d	0.17 ± 0.02^c

^aP < 0.05 vs GES-1.

^bP < 0.01 vs GES-1.

^cP < 0.05 vs AGS.

^dP < 0.01 vs AGS.

PIK3CA: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; HSP90AA1: Heat shock protein 90 alpha family class A member 1; PIK3R1: Phosphoinositide-3-kinase regulatory subunit 1; AKT1: AKT serine/threonine kinase 1; TP53: Tumor protein p53; BXD: Banxia Xiexin decoction; LY: LY294002.

Citation: Zu GX, Tang JQ, Huang HL, Han T. Validation and analysis of key factors of Banxia Xiexin decoction against gastric cancer. World J Gastrointest Oncol 2025; 17(5): 104737
URL: https://www.wjgnet.com/1948-5204/full/v17/i5/104737.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i5.104737