Simvastatin inhibits proliferation and migration, promotes oxidative stress and ferroptosis in colon cancer

Figure 4 Knockdown of SERPINE1 activates the cyclic guanosine monophosphate-protein kinase G signaling pathway in HCT-116 and SW620 cells. A and B: The transfection efficiency of single-cell RNA sequencing reveals SERPINE1 by real time polymerase chain reaction (PCR) and Western blot; C and D: The expression of GUCY1B1 and PRKG1 analyzed by real time PCR and Western blot. ^cP < 0.001. ³P vs single-cell RNA sequencing reveals-negative control group. ⁴P vs single-cell RNA sequencing reveals SERPINE1 group. si-NC: Single-cell RNA sequencing reveals-negative control; si-SERPINE1: Single-cell RNA sequencing reveals SERPINE1; cGMP: Cyclic guanosine monophosphate-protein.