Simvastatin inhibits proliferation and migration, promotes oxidative stress and ferroptosis in colon cancer

Figure 1 Effects of simvastatin on cell viability, proliferation, migration, and apoptosis in HCT-116 and SW620 cells. A: Cell viability detected by cell counting kit-8 assay; B: Cell proliferation detected by colony formation assay; C: Cell migration measured by Transwell assay; D: Cell apoptosis detected by flow cytometry; E: The expression of Ki-67, proliferating cell nuclear antigen, MMP2, MMP9, Bcl-2 and Bax analyzed by Western blot. ^aP < 0.05. ^bP < 0.01. ^cP < 0.001. ¹P vs control group. PCNA: Proliferating cell nuclear antigen.