Novel tumor marker index combining carcinoembryonic antigen and carbohydrate antigen 19-9: New prognostic factor for metastatic colorectal cancer

doi:10.4251/wjgo.v17.i5.104341

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May 15, 2025 (publication date) through Aug 9, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. May 15, 2025; 17(5): 104341
Published online May 15, 2025. doi: 10.4251/wjgo.v17.i5.104341

Table 2 Patients’ treatment responses according to the tumor marker index high and tumor marker index low groups, n (%)

	Total (n = 305)	TMI-low (n = 151)	TMI-high (n = 154)	P value
Best response				0.19
CR	20 (6.6)	14 (9.2)	6 (3.9)
PR	116 (38)	57 (37.7)	59 (38.3)
SD	102 (33.4)	46 (30.5)	56 (36.4)
PD	40 (13.1)	17 (11.3)	23 (14.9)
Missing/unknown	27 (8.9)	17 (11.3)	10 (6.5)
Objective response rate (CR + PR)	136 (44.6)	71 (47.0)	65 (42.2)	0.40
Disease control rate (CR + PR + SD)	238 (78)	117 (77.5)	121 (78.6)	0.82

TMI: Tumor marker index; CR: Complete response; PR: Partial remission; SD: Stable disease; PD: Progressive disease.

Citation: Ilhan Y, Balcik OY, Guzel HG, Onder AH, Demir B, Baser MN, Karadag I, Ozbay MF, Genc TB, Uzuntas S, Poyrazoglu O, Beypinar I, Ergun Y, Ozturk B. Novel tumor marker index combining carcinoembryonic antigen and carbohydrate antigen 19-9: New prognostic factor for metastatic colorectal cancer. World J Gastrointest Oncol 2025; 17(5): 104341
URL: https://www.wjgnet.com/1948-5204/full/v17/i5/104341.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i5.104341