Long noncoding RNA SNHG5 promotes 5-fluorouracil resistance in colorectal cancer by regulating miR-26b/p-glycoprotein axis

Figure 1 Upregulated SNHG5 expression is associated with 5-fluorouracil resistance in colorectal cancer. A and B: The expression levels of SNHG5 were assessed in collected samples [normal tissues = 16, colorectal cancer (CRC) tissues = 36] and The Cancer Genome Atlas database; C: The expression of SNHG5 was evaluated by quantitative real-time polymerase chain reaction (qRT-PCR) in CRC cell lines (LOVO, HT-29, HCT-8, and SW116) compared to normal colorectal epithelial cell line; D: The expression levels of SNHG5 were examined in the 5-fluorouracil (5-Fu)-sensitive and 5-Fu-resistant CRC groups; E and F: SNHG5 expression levels in HT-29 and HT-29/5-Fu or LOVO and LOVO/5-Fu cells were assessed by qRT-PCR. ^bP < 0.01. 5-Fu: 5-fluorouracil; CRC: Colorectal cancer.