Plexin domain-containing 1 may be a biomarker of poor prognosis in hepatocellular carcinoma patients, may mediate immune evasion

doi:10.4251/wjgo.v16.i5.2091

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. May 15, 2024; 16(5): 2091-2112
Published online May 15, 2024. doi: 10.4251/wjgo.v16.i5.2091

Table 2 Univariate and multivariate Cox regression analysis of overall survival in 123 hepatocellular carcinoma patients

Variables	Overall survival		P value
Variables	HR	95%CI	P value
Univariate analysis
Age	1.320	0.753-2.315	0.332
Gender	0.972	0.678-1.395	0.878
Tumor size	1.168	0.666-2.049	0.588
AFP (ng/mL, ≤ 20/> 20)	1.397	0.771-2.532	0.270
Cirrhosis	2.474	1.376-4.449	0.002^b
ALBI score	2.254	1.275-3.975	0.005^b
APRI score	1.787	1.014-3.149	0.045^a
HBV	0.487	0.217-1.089	0.080
PLXDC1 expression	2.714	1.524-4.832	0.001^b
Multivariate analysis
Age	1.273	0.719-2.256	0.408
Gender	1.101	0.753-1.611	0.619
Tumor size	1.128	0.633-1.208	0.683
AFP (ng/mL, ≤ 20/> 20)	0.645	0.324-1.284	0.212
Cirrhosis	0.513	0.219-1.204	0.010^a
ALBI score	2.384	1.384-4.217	0.003^b
APRI score	1.941	1.096-3.435	0.023^a
HBV	0.448	0.196-1.027	0.125
PLXDC1 expression	2.583	1.137-4.993	0.005^b

^aP < 0.05.

^bP < 0.01.

CI: Confidence interval; HR: Hazard ratio; ALBI: Albumin-bilirubin; APRI: Aspartate aminotransferase to platelet ratio; AFP: Alpha-fetoprotein; HBV: Hepatitis B virus; PLXDC1: Plexin domain-containing 1.

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Citation: Tang MY, Shen X, Yuan RS, Li HY, Li XW, Jing YM, Zhang Y, Shen HH, Wang ZS, Zhou L, Yang YC, Wen HX, Su F. Plexin domain-containing 1 may be a biomarker of poor prognosis in hepatocellular carcinoma patients, may mediate immune evasion. World J Gastrointest Oncol 2024; 16(5): 2091-2112
URL: https://www.wjgnet.com/1948-5204/full/v16/i5/2091.htm
DOI: https://dx.doi.org/10.4251/wjgo.v16.i5.2091

Tang MY, Shen X, Yuan RS, Li HY, Li XW, Jing YM, Zhang Y, Shen HH, Wang ZS, Zhou L, Yang YC, Wen HX, Su F. Plexin domain-containing 1 may be a biomarker of poor prognosis in hepatocellular carcinoma patients, may mediate immune evasion. World J Gastrointest Oncol 2024; 16(5): 2091-2112 [PMID: 38764846 DOI: 10.4251/wjgo.v16.i5.2091]

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