High patatin like phospholipase domain containing 8 expression as a biomarker for poor prognosis of colorectal cancer

Table 3 Cox regression analyses for overall survival of colorectal cancer patients in this study

Variates	Overall survival
	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
PNPLA8		0.004		0.038
Low	1 (reference)		1 (reference)
High	1.472 (1.132-1.914)		1.328 (1.016-1.734)
Age in yr		0.561
≤ 60	1 (reference)
> 60	1.079 (0.835-1.394)
Sex		0.087		0.903
Male	1 (reference)		1 (reference)
Female	0.792(0.606-1.304)		0.903 (0.687-1.187)
CEA in ng/mL		< 0.001		0.811
≤ 5	1 (reference)		1 (reference)
> 5	2.126(1.636-2.763)		0.964 (0.715-1.300)
CA199 in U/mL		< 0.001		0.004
≤ 37	1 (reference)		1 (reference)
> 37	2.870 (2.191-3.759)		1.548 (1.150-2.083)
Tumor location		0.050		0.895
Right-sided colon	1 (reference)		1 (reference)
Left-sided colon	0.952 (0.687-1.320)		0.933 (0.667-1.305)
Rectum	0.706 (0.518-0.962)		0.934 (0.680-1.284)
Tumor size in cm		0.512
≤ 4.0	1 (reference)
> 4.0	1.090 (0.843-1.409)
Primary histological type		0.371
Non-mucinous	1 (reference)
Mucinous	0.854 (0.603-1.208)
Primary differentiation		0.002		0.162
Well/moderate	1 (reference)		1 (reference)
Poor/anaplastic	1.507 (1.162-1.954)		1.210 (0.926-1.581)
T stage		< 0.001		0.163
T1/T2	1 (reference)		1 (reference)
T3/T4	3.058 (1.934-4.834)		1.415 (0.869-2.306)
N stage		< 0.001		< 0.001
N0	1 (reference)		1 (reference)
N1/N2	2.948 (2.852-3.859)		1.701 (1.272-2.274)
M stage		< 0.001		< 0.001
M0	1 (reference)		1 (reference)
M1	7.193 (5.520-9.372)		4.862 (3.608-6.551)
Vascular invasion		< 0.001		0.017
No	1 (reference)		1 (reference)
Yes	2.265 (1.649-3.111)		1.512 (1.078-2.121)
Nerve invasion		< 0.001		0.218
No	1 (reference)		1 (reference)
Yes	2.901 (1.986-4.236)		1.291 (0.860-1.939)

CA199: Carbohydrate antigen 19-9; CEA: Carcinoembryonic antigen; HR: Hazard ratio; M: Presence of metastasis; N: Extent of tumor spread to the lymph nodes; PNPLA8: Patatin like phospholipase domain containing 8; T: Extent of the tumor (the size of the tumor and any spread of tumor into nearby tissue).