High patatin like phospholipase domain containing 8 expression as a biomarker for poor prognosis of colorectal cancer

Table 2 Correlations between patatin like phospholipase domain containing 8 expression and clinicopathological parameters of colorectal cancer patients in this study

Variables	PNPLA8 expression		P value
	Low (%)	High (%)
All patients	331	420
Age in yr			0.811
≤ 60	155 (46.8)	193 (46.0)
> 60	176 (53.2)	227 (54.0)
Sex			0.375
Male	199 (60.1)	239 (56.9)
Female	132 (39.9)	181 (43.1)
CEA in ng/mL			0.821
≤ 5	173 (52.3)	223 (53.1)
> 5	158 (47.7)	197 (46.9)
CA199 in U/mL			0.900
≤ 37	267 (80.7)	340 (81.0)
> 37	64 (19.3)	80 (19.0)
Tumor location			0.434
Right-sided colon	97 (29.3)	112 (26.7)
Left-sided colon	92 (27.8)	108 (25.7)
Rectum	142 (42.9)	200 (47.6)
Tumor size in cm			0.589
≤ 4.0	185 (55.9)	243 (57.9)
> 4.0	146 (44.1)	177 (42.1)
Primary histological type			0.848
Non-mucinous	283 (85.5)	357 (85.0)
Mucinous	48 (14.5)	63 (15.0)
Primary differentiation			0.160
Well/moderate	210 (63.4)	287 (68.3)
Poor/anaplastic	121 (36.6)	133 (31.7)
T stage			0.618
T1/T2	66 (19.9)	90 (21.4)
T3/T4	265 (80.1)	330 (78.6)
N stage			0.684
N0	180 (54.4)	230 (54.8)
N1	106 (32.0)	125 (29.8)
N2	45 (13.6)	65 (15.4)
Vascular invasion			0.710
No	287 (86.7)	368 (87.6)
Yes	44 (13.3)	52 (12.4)
Nerve invasion			0.638
No	308 (93.1)	387 (92.1)
Yes	23 (6.9)	33 (7.9)
M stage			0.048
M0	256 (77.3)	298 (71.0)
M1	75 (22.7)	122 (29.0)

CA199: Carbohydrate antigen 19-9; CEA: Carcinoembryonic antigen; PNPLA8: Patatin like phospholipase domain containing 8; M: Presence of metastasis; N: Extent of tumor spread to the lymph nodes; T: Extent of the tumor (the size of the tumor and any spread of tumor into nearby tissue).