Impact of Alcian blue and periodic acid Schiff expression on the prognosis of gastric signet ring cell carcinoma

Table 2 Univariate and multivariate Cox regression analysis based on clinicopathologic parameters for 83 signet ring cell carcinoma patients

	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
Age (yr)
≤ 60	1
> 60	1.461	0.624-3.418	0.382
Gender
Male	1
Female	0.865	0.384-1.949	0.727
Tumor diameter
≤ 3	1			1
> 3	4.428	1.750-11.199	0.002	2.761	1.086-7.020	0.033
Venous tumor emboli
No	1
Yes	3.634	1.351-9.775	0.011
Lymph node metastasis
No	1
Yes	3.006	1.120-8.066	0.029
Tumor stage
Early	1			1
Advanced	42.232	1.201-1485.160	0.039	159858	0.000-2.26E+153	0.945
Ki67
≤ 50%	1
> 50%	2.254	0.984-5.165	0.055
P53
Negative	1
Positive	2.532	0.995-6.443	0.051
HER2
Negative	1
Positive	1.232	0.487-3.114	0.659
PAS
> 50%	1			1
≤ 50%	5.284	2.164-12.905	0	3.809	0.108-0.640	0.003
AB
≤ 50%	1
> 50%	0.985	0.970-3.114	1.002
A/P
≤ 50%	1
> 0.5	1.402	1.028-1.910	0.033

P < 0.05 is considered statistically significant. AB: Alcian blue; A/P: Alcian blue to periodic acid Schiff ratio; CI: Confidence interval; HR: Hazard ratio; PAS: Periodic acid-Schiff.