Mechanism of pachymic acid in the treatment of gastric cancer based on network pharmacology and experimental verification

Figure 3 Enrichment analysis. A: Gene Ontology enrichment analysis; B: Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis; C: Protein-protein interaction network diagram of KEGG pathways and top 12 core targets, green represents pathways and red represents core targets; D: Gene set enrichment analysis analyzed the results; E: PI3K/AKT signaling pathway. GF: Growth factor; PAMP: Pathogen-associated molecular patterns; ECM: von Willebrand factor; TLR2/4: Toll-like receptor 2/4; BCR: Breakpoint cluster region protein; ITGA: Integrin alpha; ITGB: Integrin beta; PDK1: Pyruvate dehydrogenase kinase 1; PP2A: Serine/threonine-protein phosphatase 2A catalytic subunit; TCL1: T-cell leukemia/lymphoma protein 1A; HSP90: Heat shock protein 90; mTORC2: CREB-regulated transcription coactivator 2; PHLPP: PH domain leucine-rich repeat-containing protein phosphatase 1; BAD: Bcl2-associated agonist of cell death; CREB: Ubiquitin carboxyl-terminal hydrolase creB.