Comprehensive analysis of distal-less homeobox family gene expression in colon cancer

Table 1 Univariate and multivariate Cox regression analyses with distal-less homeobox genes and prognosis of colon adenocarcinoma patients

Survival	Characteristics	Total, n	Univariate analysis		Multivariate analysis
			HR (95%CI)	P value	HR (95%CI)	P value
Overall	DLX1 (low vs high)	477	1.299 (0.880-1.917)	0.186
	DLX2 (low vs high)	477	1.736 (1.167-2.584)	0.007	1.502 (0.988-2.285)	0.057
	DLX3 (low vs high)	477	1.668 (1.123-2.476)	0.011	1.374 (0.900-2.099)	0.142
	DLX4 (low vs high)	477	1.538 (1.039-2.276)	0.031	1.197 (0.783-1.830)	0.405
	DLX5 (low vs high)	477	1.485 (1.001-2.202)	0.049	1.334 (0.893-1.993)	0.159
	DLX6 (low vs high)	477	0.935 (0.634-1.379)	0.734
Progression-free	DLX1 (low vs high)	477	1.557 (1.094-2.214)	0.014	1.316 (0.901-1.921)	0.155
	DLX2 (low vs high)	477	1.715 (1.201-2.449)	0.003	1.317 (0.883-1.964)	0.178
	DLX3 (low vs high)	477	1.670 (1.174-2.376)	0.004	1.365 (0.937-1.990)	0.105
	DLX4 (low vs high)	477	1.497 (1.054-2.125)	0.024	1.181 (0.813-1.715)	0.382
	DLX5 (low vs high)	477	1.742 (1.217-2.492)	0.002	1.588 (1.105-2.283)	0.012
	DLX6 (low vs high)	477	0.914 (0.646-1.294)	0.613
Disease specific	DLX1 (low vs high)	461	1.426 (0.865-2.349)	0.164
	DLX2 (low vs high)	461	2.014 (1.202-3.376)	0.008	1.666 (0.971-2.857)	0.064
	DLX3 (low vs high)	461	2.007 (1.202-3.349)	0.008	1.570 (0.909-2.713)	0.106
	DLX4 (low vs high)	461	1.617 (0.981-2.664)	0.059	1.179 (0.692-2.011)	0.545
	DLX5 (low vs high)	461	2.011 (1.193-3.390)	0.009	1.765 (1.039-2.998)	0.035
	DLX6 (low vs high)	461	0.852 (0.520-1.395)	0.524

CI: Confidence interval; DLX: Distal-less homeobox; HR: Hazard ratio.