Real-world 10-year retrospective study of the guidelines for diagnosis and treatment of primary liver cancer in China

Table 6 Analysis of overall survival in patients with hepatocellular carcinoma

Variables	Univariate analysis	Multivariate analysis
	P value	P value	Hazard ratio (95%CI)
Sex	0.5736	—
Age (> 50)	0.0074a	0.0087b	1.359 (1.081–1.709)
Screening	< 0.001b	0.0003b	2.181 (1.435–3.313)
HBV	0.0703	—
HCV	0.0354	—
Child-Pugh grade	< 0.001b
A			1 reference
B		< 0.001b	1.813 (1.480–2.252)
C		0.3798	1.274 (0.742–2.190)
CNLC staging	< 0.001b
Early			1 reference
Middle		< 0.001b	2.610 (2.056–3.312)
Late		< 0.001b	3.967 (2.827–5.591)
AFP (ng/mL)	< 0.001b
≤ 20			1 reference
20–400		0.615	1.070 (0.822–1.392)
> 400		< 0.001b	1.576 (1.256–1.977)

^aP < 0.05.

^bP < 0.01.

CI: Confidence interval; HCC: Hepatocellular carcinoma; HBV: Hepatitis B virus; HCV: Hepatitis C virus; CNLC: China Liver Cancer staging, AFP: Alpha-fetoprotein.