F-box and leucine-rich repeat 6 promotes gastric cancer progression via the promotion of epithelial-mesenchymal transition

Figure 3 F-box and leucine-rich repeat 6 regulates gastric cancer cell migration. A and B: Wound healing analysis to assess the migration of F-box and leucine-rich repeat 6 (FBXL6) knockdown stable cell lines or overexpression of FBXL6 in MGC-803 cells at 0 h and 24 h; C and D: Cell migration and invasion of gastric cancer cells with (C) knockdown of FBXL6 or (D) overexpression of FBXL6 by transwell assay. E and F: The experimental results revealed that the knockdown of FBXL6 significantly reduced migration and invasion of MKN-45 cells (E), whereas the overexpression of FBXL6 increased migration in MGC-803 (F). ^bP < 0.01; ^cP < 0.001. FBXL6: F-box and leucine-rich repeat 6.