Cancerous inhibitor of protein phosphatase 2A enhances chemoresistance of gastric cancer cells to oxaliplatin

doi:10.4251/wjgo.v15.i2.286

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Feb 15, 2023 (publication date) through May 4, 2024

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World Journal of Gastrointestinal Oncology

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1948-5204

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World J Gastrointest Oncol. Feb 15, 2023; 15(2): 286-302
Published online Feb 15, 2023. doi: 10.4251/wjgo.v15.i2.286

Table 3 Univariate and multivariate analyses of progression-free survival in patients with gastric cancer

Prognostic variables	Univariate analysis			Multivariate analysis
Prognostic variables	Hazard ratio	95% confidence interval	P value	Hazard ratio	95% confidence interval	P value
Sex	0.973	0.574–1.650	0.919	-	-	-
Age	1.363	0.814–2.281	0.239	-	-	-
Tumor location	0.913	0.538–1.548	0.735	-	-	-
Histological grade	0.73	0.417–1.278	0.27	-	-	-
Tumor size	2.43	1.407–4.197	0.004^a	0.869	0.504–1.499	0.614
T stage	3.15	1.669–5.943	0.000^a	2.644	1.294–5.420	0.009^a
N stage	2.044	1.202–3.476	0.008^a	1.451	0.728–2.891	0.29
TNM stage	1.917	1.150–3.194	0.013^a	0.88	0.452–1.713	0.88
CIP2A expression	2.309	1.282–3.911	0.003^a	1.821	1.021–3.247	0.042^a

^aP < 0.05.

T: Tumor; N: Node; TNM: Tumor Node Metastasis; CIP2A: Cancerous inhibitor of protein phosphatase 2A.

Citation: Zhao YX, Ma LB, Yang Z, Wang F, Wang HY, Dang JY. Cancerous inhibitor of protein phosphatase 2A enhances chemoresistance of gastric cancer cells to oxaliplatin. World J Gastrointest Oncol 2023; 15(2): 286-302
URL: https://www.wjgnet.com/1948-5204/full/v15/i2/286.htm
DOI: https://dx.doi.org/10.4251/wjgo.v15.i2.286