Traditional Chinese medicine for transformation of gastric precancerous lesions to gastric cancer: A critical review

Figure 1 A diagram of pathway targets of traditional Chinese medicine formulas and compounds for gastric precancerous lesions and gastric cancer. Targets involved in angiogenesis, inflammation, and proliferation and apoptosis were labelled grey, pink, and blue, respectively. Border of targets regulated in gastric precancerous lesions and gastric cancer stage were painted into green and yellow, respectively. The traditional Chinese medicine formulas and compounds regulating each target were labeled as “c” and “f”, respectively. Red and green background of “c” and “f” represent up- and down-regulation of the target, respectively. The details of number of these formulas and compounds were shown in Tables 2 and 3. HRAS: Harvey rat sarcoma viral oncogene homolog; HIF-1α: Hypoxia-inducible factor 1α; VEGF: Vascular endothelial growth factor; NF-ΚB: Noncanonical nuclear factor-kappaB; TNF-α: Tumour necrosis factor alpha; IL: Interleukin.