Efficacy of neoadjuvant chemotherapy for initially resectable colorectal liver metastases: A retrospective cohort study

Table 1 Patient characteristics before propensity score matching

Variables		Upfront hepatectomy (n = 238)	NAC (n = 59)	P value
Patient-related
Age	< 60	123	14	< 0.001
	≥ 60	115	45
Gender	Male	184	39	0.07
	Female	54	20
CEA level (ng/mL)	< 10	73	19	0.82
	≥ 10	165	40
Primary tumor-related
Site	Right	34	15	0.03
	Left	204	44
Histology	Well/moderately differentiated	236	57	0.128
	Others	2	2
Lymph node metastases	0	144	17	< 0.001
	≥ 1	94	42
Depth of invasion	Adjacent organ invasion (T4b)	14	9	0.01
	Others	224	50
Lymphatic invasion	0	146	29	0.08
	≥ 1	92	30
Venous invasion	0	91	18	0.27
	≥ 1	147	41
Liver metastasis-related
Number	1–3	233	48	< 0.001
	≥ 4	5	11
Size (max)	< 40	180	18	0.06
	≥ 40	58	41
Timing of the appearance	Synchronous	40	37	< 0.001
	Metachronous	198	22
Distribution	Unilobar	211	38	< 0.001
	Bilobar	27	21
Treatment-related
Staged hepatectomy	Performed	0	1	0.04
	Not performed	238	58
Surgical margin	Exposed	13	6	0.186
	Not exposed	225	53
Adjuvant chemotherapy after primary resection	Administered	69	32	< 0.001
	Not administered	169	27
Adjuvant chemotherapy after hepatectomy	Administered	86	23	0.684
	Not administered	152	36

CEA: Carcinoembryonic antigen; NAC: Neoadjuvant chemotherapy.