Comprehensive analysis of the potential role and prognostic value of sine oculis homeobox homolog family in colorectal cancer

Table 5 Relationship between the expression of sine oculis homeobox homolog 4 and clinicopathological parameters of colon cancer patients

Clinicopathological parameter	n	SIX4 expression		χ2	P value
		Low	High
Age
≤ 60 yr	22	10 (45.5%)	12 (54.5%)	1.558	0.2120
> 60 yr	71	22 (31.0%)	49 (69.0%)
Sex
Male	44	17 (38.6%)	27 (61.4%)	0.6614	0.4161
Female	49	15 (30.6%)	34 (69.4%)
Maximum tumor diameter1
< 5 cm	37	13 (35.1%)	24 (64.9%)	0.0034	0.9563
≥ 5 cm	55	19 (34.5%)	36 (65.5%)
Pathological stage
I-II	78	29 (37.2%)	49 (62.8%)	-	0.2470
III	15	3 (20.0%)	12 (80.0%)
Primary tumor
T1-T2	5	2 (40.0%)	3 (60.0%)	0.0696	0.9658
T3	70	24 (34.3%)	46 (65.7%)
T4	17	6 (35.3%)	11 (64.7%)
N
N0	58	24 (41.4%)	34 (58.6%)	3.318	0.0685
N1-N2	35	8 (22.9%)	27 (77.1%)

¹One patient with an undetected primary tumor was excluded.

SIX: Sine oculis homeobox homolog.