Long-term follow-up of HER2 overexpression in patients with rectal cancer after preoperative radiotherapy: A prospective cohort study

Table 3 Correlations among distant metastasis and the clinicopathological parameters

Variable	Distant metastasis		χ2	P value
	- (%)	+ (%)
Age (yr)			0.121	0.728
< 60	52 (59.1)	36 (40.9)
≥ 60	39 (61.9)	24 (38.1)
Sex			0.446	0.504
Male	58 (62.4)	35 (37.6)
Female	33 (56.9)	25 (43.1)
Pre-CEA			9.704	0.002
Normal range	68 (69.4)	30 (30.6)
Elevated	23 (43.4)	30 (56.6)
Distance to anal verge (cm)			0.103	0.749
> 6	28 (62.2)	17 (37.8)
≤ 6	63 (59.4)	43 (40.6)
Pre-T				0.2211
T1-2	5	7
T3-4	86	53
Pre-N			0.001	1.000
N0	23 (60.5)	15 (39.5)
N+	68 (60.2)	45 (39.8)
Post-T			3.782	0.052
T1-2	43	18
T3-4	48	42
Post-N			7.995	0.005
N0	62 (69.7)	27 (30.3)
N+	29 (46.8)	33 (53.2)
LVI			1.014	0.314
+	10 (50.0)	10 (50.0)
-	81 (61.8)	50 (38.2)
HER2, number			9.959	0.002
-	82 (66.1)	42 (33.9)
+	9 (33.3)	18 (66.7)

¹Fisher’s exact test.