Long-term follow-up of HER2 overexpression in patients with rectal cancer after preoperative radiotherapy: A prospective cohort study

Table 1 Clinicopathological characteristics of the enrolled cohort (n = 151)

Characteristic	Result
Age diagnosis (yr)	55.85 ± 13.26
Gender (%)
Male	93 (61.6)
Female	58 (38.4)
Distance to anal verge (cm) (%)	4.91 ± 2.04
> 6	45 (29.8)
≤ 6	106 (70.2)
Pre-CEA (%)
Normal range	98 (64.9)
Elevated	53 (35.1)
Pre-T (%)
T1	2 (1.3)
T2	10 (6.6)
T3	133 (88.1)
T4	6 (4.0)
Pre-N (%)
N0	38 (25.2)
N+	113 (74.8)
Post-T (%)
pT0	7 (4.6)
pT1	6 (4.0)
pT2	48 (31.8)
pT3	84 (55.6)
pT4	4 (4.0)
Post-N (%)
pN0	89 (58.9)
pN+	62 (41.1)
Tumor regression grade (%)
Grade 0	9 (6.3)
Grade 1	34 (23.9)
Grade 2	42 (29.6)
Grade 3	57 (40.1)
HER2 (%)
-	124 (82.1)
+	27 (17.9)
LVI (%)
+	20 (13.2)
-	131 (86.8)
Median follow-up period	134
Distant metastasis, number (%)
Yes	60 (39.7)
No	91 (60.3)
Local recurrence, number (%)
Yes	24 (15.9)
No	127 (84.1)

Pre-CEA: Preoperative CEA; LVI: Lympho-vascular invasion.