Immune aspects of hepatocellular carcinoma: From immune markers for early detection to immunotherapy

Table 1 Recommended treatments for hepatocellular carcinoma according to the Barcelona Clinic Liver Cancer staging system

BCLC stages	Recommended treatments1
Very early (0)	Resection or ablation
Early (A)	Transplant, resection or ablation
Intermediate (B)	Transarterial chemoembolization
Advanced (C)	Systemic therapy2
Terminal (D)	Best supportive care

¹Treatments recommended by the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver guidelines (2018)[7-9].

²First-line therapy: Sorafenib or lenvatinib. Second-line therapy: Regorafenib, cabozantinib or nivolumab. Third line therapy: Cabozantinib. BCLC: Barcelona Clinic Liver Cancer staging system.