Serum vascular endothelial growth factor as a tumor marker for hepatocellular carcinoma in hepatitis C virus-related cirrhotic patients

Table 3 Diagnostic performance of alpha fetoprotein, vascular endothelial growth factor, and vascular endothelial growth factor/platelet, separately and in combination, in the prediction of hepatocellular carcinoma

	Cut-off point	AUC	Sensitivity	Specificity	Accuracy	PPV	NPV	P value
AFP	40	0.754	65.00	83.33	74.17%	72.2	78.1	< 0.0001
VEGF	250	0.859	80.00	81.67	80.84	74.4	86.0	< 0.0001
VEGF/PLT	2.31	0.842	77.50	80.00	78.75	72.1	84.2	< 0.0001
Combination	--	0.953	92.50	98.33	95.42	97.4	95.2	< 0.0001

AUC: Area under the receiver operating characteristic curve; PPV: Positive predictive value; NPV: Negative predictive value; AFP: Alpha fetoprotein; VEGF: Vascular endothelial growth factor; PLT: Platelet.