Genome-wide CRISPR-Cas9 screening identifies that hypoxia-inducible factor-1a-induced CBX8 transcription promotes pancreatic cancer progression via IRS1/AKT axis

Figure 2 Higher CBX8 expression induces worse clinical outcome in pancreatic cancer tissue. A: The mRNA expression of CBX8 in 116 paired pancreatic cancer (PC) and normal tissues measured by quantitative reverse transcription-PCR; B: Kaplan–Meier survival of patients with high and low CBX8 mRNA level; C: Protein expression of CBX8 in 20 paired PC and normal tissues measured by Western blot; D: Heatmap indicating genes positively related with CBX8; E: KEGG pathway analysis of genes in positive relation with CBX8. ^bP < 0.01.