Clinical significance of expression of fibrous sheath interacting protein 1 in colon cancer

Table 3 Relative mortality risk (n = 302) based on univariate and multivariate Cox regression analyses of clinical pathological parameters and high fibrous sheath interacting protein 1 expression

Characteristic	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age		0.899		0.675
≤ 60	1 (Ref)		1 (Ref)
> 60	0.972 (0.721-1.322)	0.899	1.019 (0.732–1.418)	0.675
Sex		0.674		0.739
Male	1 (Ref)		1 (Ref)
Female	1.558 (0.731-2.235)	0.674	2.339 (0.610-3.886)	0.739
Tumor size		0.003		0.219
< 5	1 (Ref)		1 (Ref)
5-10	1.427 (0.973-1.886)	0.043	1.339 (0.921-1.992)	0.198
> 10	1.661 (1.095-2.291)	0.005	1.431 (0.695-1.832)	0.399
Pathological tumor stage		0.000
T1	1 (Ref)		1 (Ref)	0.000
T2	2.521 (1.567-4.631)	0.001	1.330 (1.009-2.461)	0.002
T3	3.213 (2.288–9.198)	0.000	3.445 (1.925-4.901)	0.000
T4	4.883 (1.528–5.438)	0.000	4.870 (2.062-9.126)	0.000
Pathological nodal stage		0.000		0.000
N0	1 (Ref)		1 (Ref)
N1	1.916 (1.379-3.221)	0.003	1.687 (1.563-6.019)	0.002
N2	4.422 (1.837-7.622)	0.000	6.819 (3.421-12.567)	0.000
N3	9.230 (4.399-12.257)	0.000	7.909 (3.963-16.878)	0.000
Tumor differentiation		0.000		0.000
Well	1 (Ref)		1 (Ref)
Mediate	4.696 (1.565-8.912)	0.000	5.229 (4.442-9.887)	0.000
Poor	7.129 (3.126-11.703)	0.000	6.443 (2.126-12.556)	0.000
FSIP1 expression
Negative	1 (Ref)		1 (Ref)
Positive	2.933 (2.067-4.559)	0.000	2.661 (1.979-5.635)	0.001

The results showed that the hazard ratio of fibrous sheath interacting protein 1 positivity in terms of risk of death was 2.933 (95%CI: 2.067-4.559; P = 0.001). After adjusting for other baseline parameters (including age, sex, tumour size, pathological T stage, lymph node metastasis N stage, and tumour differentiation), the hazard ratio of fibrous sheath interacting protein 1 positivity in terms of risk of death changed minimally (hazard ratio = 2.661, 95%CI: 1.979-5.635; P = 0.001). CI: Confidence interval; HR: Hazard ratio; Ref: Reference category.