Characterization and strong risk association of TLR2 del -196 to -174 polymorphism and Helicobacter pylori and their influence on mRNA expression in gastric cancer

doi:10.4251/wjgo.v12.i5.535

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. May 15, 2020; 12(5): 535-548
Published online May 15, 2020. doi: 10.4251/wjgo.v12.i5.535

Table 5 TLR2 gene expression level groups to assess influence of polymorphic genotypes in gastric cancer and chronic gastritis

Groups		*TLR2-196 to -174ins/del*		P value	TLR2-19216 T/C		P value
		*ins/ins*	*ins/del + del/del*	P value	TT	*TC/CC*	P value
GC (n = 36)	Median	2.58	8.74	0.0010¹	18.54	3.63	0.0004¹
GC (n = 36)	Interquartile range	1.45-7.26	7.50-34.66	0.0010¹	11.82-35.55	1.62-7.76	0.0004¹
CG (n = 48)	Median	0.92	0.79	0.5334	0.92	0.71	0.8827
CG (n = 48)	Interquartile range	0.56-1.09	0.48-1.92	0.5334	0.53-1.53	0.49-1.44	0.8827

¹Mann Whitney U Test. Data are presented as the relative quantification (RQ) median with interquartile range. Significant difference (P < 0.05).

Citation: Lourenço CM, Susi MD, Nascimento MCAD, Serafim Junior V, Vila APS, Rodrigues-Flemming GH, Goloni-Bertollo EM, Silva AE, Oliveira-Cucolo JG. Characterization and strong risk association of TLR2 del -196 to -174 polymorphism and Helicobacter pylori and their influence on mRNA expression in gastric cancer. World J Gastrointest Oncol 2020; 12(5): 535-548
URL: https://www.wjgnet.com/1948-5204/full/v12/i5/535.htm
DOI: https://dx.doi.org/10.4251/wjgo.v12.i5.535