Comparison of prognostic factors in different age groups and prognostic significance of neutrophil-lymphocyte ratio in patients with gastric cancer

Table 6 Univariate and multivariate analyses of overall survival of 651 gastric cancer patients in middle-age group (45 ≤ age < 70).

Characteristic	Univariate	Analysis	Multivariate	Analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Sex (Male/Female)		0.953
Hospitalization (≥ 18/< 18 mo)	1.546 (1.210-1.976)	0.01		0.127
T stage (3 + 4/1 + 2)	8.995 (5.635-14.358)	< 0.001
N stage (1-3/0)	6.752 (4.659-9.786)	< 0.001
M stage (1/0)	5.792 (4.186-8.013)	< 0.001
TNM (III-IV/I-II)	7.558 (5.348-10.682	< 0.001	5.994 (4.183-8.590)	< 0.001
Histological type (Diffuse/Intestinal)	0.598 (0.468-0.764)	< 0.001		0.104
Location (Cardia/non-cardia)	1.481 (1.111-1.973)	0.007		0.947
Tumor size (≥ 4/< 4 cm)	2.859 (2.165-3.776)	< 0.001		0.302
Neural invasion (Y/N)	2.075 (1.596-2.696)	< 0.001		0.723
Vessel invasion (Y/N)	2.749 (2.146-3.523)	< 0.001	1.603 (1.242-2.069)	< 0.001
Esophageal invasion (Y/N)	2.209 (1.559-3.130)	< 0.001	1.431 (1.285-2.130)	0.046
NLR (≥ 2.6/< 2.6)	1.541 (1.206-1.970)	0.001		0.335
Anemia (Y/N)		0.157
PLR (≥ 133/< 133)	1.486 (1.163-1.898)	0.002		0.436
Low albumin (Y/N)	1.721 (1.216-2.438)	0.002		0.484
Low prealbumin (Y/N)	2.128 (1.656-2.735)	< 0.001	1.654 (1.285-2.130)	< 0.001
PNI (< 47/≥ 47)	1.806 (1.404-2.323)	< 0.001		0.265

TNM: Tumor–node–metastasis; NLR: Neutrophil-lymphocyte ratio; PLR: Platelet lymphocyte ratio; PNI: Prognostic nutritional index.