Prognostic significance of primary tumor localization in stage II and III colon cancer

Table 3 Factors affecting disease free survival

		Univariate analysis						Multivariate analysis
		HR		95%CI		P		HR		95%CI		P
Age (yr)	< 65	1						1
	≥ 65	1.779	1.268		2.496		0.001	1.88	1.305		2.708		0.001
Gender	Male	1
	Female	0.96	0.686		1.343		0.812
Family history	No	1
	Yes	1.195	0.489		2.919		0.696
Smoking status	No	1
	Yes	0.908	0.641		1.287		0.587
Alcohol using status	No	1
	Yes	0.372	0.118		1.167		0.09
Mode of surgery	Elective	1						1
	Emergent	1.796	1.22		2.646		0.003	1.718	1.131		2.611		0.011
DM	No	1
	Yes	0.973	0.549		1.724		0.925
HT	No	1
	Yes	1.541	0.967		2.224		0.067
Histology	Adenocarcinoma	1
	Mucinous adenocarcinoma	1.207	0.793		1.839		0.38
Tumor grade	Well and moderately	1
	Poorly	1.574	0.889		2.787		0.119
Tumor location	RCC	1
	LCC	0.997	0.714		1.392		0.984
Tumor stage	II	1						1
	III	2.99	2.109		4.238		< 0.001	2.281	1.485		3.505		< 0.001
pT stage	T1 + 2	1					< 0.001
	T2	1.912	0.999		3.662		0.05
	T4	9.308	4.478		19.348		< 0.001
Number of removed lymph nodes	≥ 12	1						1
	< 12	2.166	1.421		3.301		< 0.001	1.751	1.13		2.712		0.012
pN	N0	1					< 0.001
	N1	2.779	1.908		4.047		< 0.001
	N2	3.56	2.237		5.664		< 0.001
PNI	Negative	1						1
	Positive	3.953	2.801		5.578		< 0.001	2.277	1.549		3.347		< 0.001
LVI	Negative	1						1
	Positive	3.372	2.382		4.774		< 0.001	1.825	1.221		2.728		0.003
Surgical margin	Negative	1
	Positive	3.884	1.436		10.505		0.008
Adjuvant treatment	No	1						1
	Yes	0.591	0.346		0.954		0.041	0.514	0.323		0.82		0.005

DM: Diabetes mellitus; HT: Hypertension; Max: Maximum; Min: Minimum; LCC: Left colon cancer; LVI: Lymphovascular invasion; pN: Pathological lymph node stage; PNI: Perineural invasion; pT: Pathological tumor stage; RCC: Right colon cancer.