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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Feb 15, 2016; 8(2): 147-158
Published online Feb 15, 2016. doi: 10.4251/wjgo.v8.i2.147
Published online Feb 15, 2016. doi: 10.4251/wjgo.v8.i2.147
Role of Helicobacter pylori in gastric cancer: Updates
Jahanarah Khatoon, Ravi Prakash Rai, Kashi Nath Prasad, Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh 226014, India
Author contributions: All the authors contributed to this paper.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Kashi Nath Prasad, Professor, Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rae Bareli Road, Lucknow, Uttar Pradesh 226014, India. kashinprasad@gmail.com
Telephone: +91-522-2668631 Fax: +91-522-2668017
Received: April 28, 2015
Peer-review started: May 1, 2015
First decision: July 6, 2015
Revised: November 24, 2015
Accepted: December 13, 2015
Article in press: December 15, 2015
Published online: February 15, 2016
Peer-review started: May 1, 2015
First decision: July 6, 2015
Revised: November 24, 2015
Accepted: December 13, 2015
Article in press: December 15, 2015
Published online: February 15, 2016
Core Tip
Core tip: Although the incidence and mortality of gastric cancer (GC) is declining in recent decades but it still remains a major threat in developing countries as compared to developed one. Among various etiological agents, Helicobacter pylori (H. pylori) play a detrimental role in development of GC. Through this review we focus on the recent progress in the field of research on H. pylori induced GC and providing the brief insight into H. pylori pathogenesis, the role of major virulence factors of H. pylori that modulates the host environment and transform the normal gastric epithelium to neoplastic one.