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World J Gastrointest Oncol. Sep 15, 2014; 6(9): 311-324
Published online Sep 15, 2014. doi: 10.4251/wjgo.v6.i9.311
Published online Sep 15, 2014. doi: 10.4251/wjgo.v6.i9.311
Pathological features and diagnosis of intraductal papillary mucinous neoplasm of the pancreas
Víctor M Castellano-Megías, Department of Pathology, Hospital Universitario de Fuenlabrada, 28942 Fuenlabrada, Madrid, Spain
Carolina Ibarrola-de Andrés, Guadalupe López-Alonso, Francisco Colina-Ruizdelgado, Department of Pathology, Hospital Universitario “12 de Octubre”, 28942 Fuenlabrada, Madrid, Spain
Author contributions: Castellano-Megías VM, Ibarrola-de Andrés C, López-Alonso G and Colina-Ruizdelgado F contributed equally to this work.
Correspondence to: Dr. Víctor Manuel Castellano-Megías, Department of Pathology, Hospital Universitario de Fuenlabrada, Camino del Molino, 2, 28942 Fuenlabrada, Madrid, Spain. victormanuel.castellano@salud.madrid.org
Telephone: +34-916-006331 Fax: +34-913-908462
Received: August 21, 2013
Revised: November 7, 2013
Accepted: December 9, 2013
Published online: September 15, 2014
Revised: November 7, 2013
Accepted: December 9, 2013
Published online: September 15, 2014
Core Tip
Core tip: The authors review the main pathological features of intraductal papillary mucinous neoplasm (IPMN) of the pancreas, including diagnostic criteria and relevance of macroscopic (i.e., main duct, branch duct and mixed or combined) and microscopic (i.e., gastric, intestinal, pancreatobiliary and oncocytic) IPMN classification. Different pathways, mucin immunophenotypes and invasive carcinoma related to IPMN are addressed. Differential diagnosis with pancreatic intraepithelial neoplasm, mucinous cystic neoplasm and other mucinous and non-mucinous pancreatic cystic lesions are also included.