Xu YC, Fu DL, Yang F. Unraveling the enigma: A comprehensive review of solid pseudopapillary tumor of the pancreas. World J Gastrointest Oncol 2024; 16(3): 614-629 [PMID: 38577449 DOI: 10.4251/wjgo.v16.i3.614]
Corresponding Author of This Article
Feng Yang, MD, PhD, Doctor, Surgeon, Department of Pancreatic Surgery, Pancreatic Disease Institute, Huashan Hospital, Fudan University, No. 12 Central Urumqi Road, Shanghai 200040, China. yffudan98@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Mar 15, 2024; 16(3): 614-629 Published online Mar 15, 2024. doi: 10.4251/wjgo.v16.i3.614
Unraveling the enigma: A comprehensive review of solid pseudopapillary tumor of the pancreas
Ye-Cheng Xu, De-Liang Fu, Feng Yang
Ye-Cheng Xu, De-Liang Fu, Feng Yang, Department of Pancreatic Surgery, Pancreatic Disease Institute, Huashan Hospital, Fudan University, Shanghai 200040, China
Author contributions: Xu YC and Yang F contributed to data acquisition, and drafting the article; Fu DL and Yang F contributed to the conception and design of this paper; all authors contributed to the final approval of the version to be published.
Conflict-of-interest statement: We declare no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Feng Yang, MD, PhD, Doctor, Surgeon, Department of Pancreatic Surgery, Pancreatic Disease Institute, Huashan Hospital, Fudan University, No. 12 Central Urumqi Road, Shanghai 200040, China. yffudan98@126.com
Received: November 9, 2023 Peer-review started: November 9, 2023 First decision: December 18, 2023 Revised: December 28, 2023 Accepted: January 16, 2024 Article in press: January 16, 2024 Published online: March 15, 2024
Core Tip
Core Tip: Solid pseudopapillary tumor of the pancreas (SPTP) is a rare neoplasm predominantly affecting young females. Pathologically, CTNNB1 mutations, β-catenin nuclear accumulation, and Wnt signaling pathway activation are key molecular features. Accurate preoperative diagnosis relies on imaging and endoscopic biopsies. Surgical resection is the main treatment, and prognostic models like Fudan Prognostic Index aid in prognosis assessment. Challenges in understanding its etiology, establishing treatments for unresectable/metastatic disease, and developing a standardized grading system persist. This comprehensive review aims to consolidate current knowledge on epidemiology, clinical presentation, pathology, molecular features, and treatment options for SPTP.
