Editorial
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Mar 15, 2024; 16(3): 571-576
Published online Mar 15, 2024. doi: 10.4251/wjgo.v16.i3.571
Synchronous gastric and colon cancers: Important to consider hereditary syndromes and chronic inflammatory disease associations
Santosh Shenoy
Santosh Shenoy, Department of General Surgery, Kansas City VA Medical Center, University of Missouri-Kansas City, Kansas, MO 64128, United States
Author contributions: Shenoy S designed the overall concept and outline of the manuscript and the writing, discussion, editing the manuscript, and review of literature.
Conflict-of-interest statement: The author has no conflict of interest to disclose or any funding for this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Santosh Shenoy, FACS, MD, Professor, Surgeon, Department of General Surgery, Kansas City VA Medical Center, University of Missouri-Kansas City, 4801 E Linwood, Kansas, MO 64128, United States. shenoy2009@hotmail.com
Received: October 31, 2023
Peer-review started: October 31, 2023
First decision: December 18, 2023
Revised: December 23, 2023
Accepted: January 30, 2024
Article in press: January 30, 2024
Published online: March 15, 2024
Core Tip

Core Tip: Certain genetic polyposis syndromes and inflammatory familial diseases are associated with increased risks for multiple site gastrointestinal cancer, specifically gastroduodenal and colon cancers. These include familial adenomatous polyposis, Lynch syndromes, Hereditary diffuse gastric cancer, Peutz-Jeghers syndrome, Crohn’s disease. Mutations in APC gene, MMR genes, CDH1 gene and STK11 gene respectively. Generally, cancers associated with genetic mutations progress through adenoma carcinoma sequence while inflammatory bowel disease progress to malignancy through dysplasia-carcinoma sequence.