Tortora SC, Bodiwala VM, Quinn A, Martello LA, Vignesh S. Microbiome and colorectal carcinogenesis: Linked mechanisms and racial differences. World J Gastrointest Oncol 2022; 14(2): 375-395 [PMID: 35317317 DOI: 10.4251/wjgo.v14.i2.375]
Corresponding Author of This Article
Shivakumar Vignesh, AGAF, FACG, FASGE, MD, Associate Professor, Department of Medicine and Division of Gastroenterology & Hepatology, SUNY Downstate Health Sciences University, 450 Clarkson Avenue, Brooklyn, NY 11203, United States. vignesh185@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Feb 15, 2022; 14(2): 375-395 Published online Feb 15, 2022. doi: 10.4251/wjgo.v14.i2.375
Microbiome and colorectal carcinogenesis: Linked mechanisms and racial differences
Sofia C Tortora, Vimal M Bodiwala, Andrew Quinn, Laura A Martello, Shivakumar Vignesh
Sofia C Tortora, Vimal M Bodiwala, Andrew Quinn, Laura A Martello, Shivakumar Vignesh, Department of Medicine and Division of Gastroenterology & Hepatology, SUNY Downstate Health Sciences University, Brooklyn, NY 11203, United States
Author contributions: Tortora SC, Bodiwala VM and Quinn A wrote the manuscript; Tortora SC wrote Table; Martello LA and Vignesh S edited and added to manuscript; all authors have read and approve the final manuscript.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shivakumar Vignesh, AGAF, FACG, FASGE, MD, Associate Professor, Department of Medicine and Division of Gastroenterology & Hepatology, SUNY Downstate Health Sciences University, 450 Clarkson Avenue, Brooklyn, NY 11203, United States. vignesh185@gmail.com
Received: July 13, 2021 Peer-review started: July 13, 2021 First decision: July 29, 2021 Revised: August 26, 2021 Accepted: January 14, 2022 Article in press: January 14, 2022 Published online: February 15, 2022
Core Tip
Core Tip: In this review, we describe oral and gut microbiome associated with colorectal (CRC) carcinogenesis in relation to the “hallmarks of cancer” and microbial diversity and abundance between races/ethnicities. CRC patients showed increased levels of Bacteroides, Prevotella, Escherichia coli, enterotoxigenic Bacteroides fragilis, Streptococcus gallolyticus, Enterococcus faecalis, Fusobacterium nucleatum (F. nucleatum) and Clostridium difficile. Higher levels of Bacteroides, F. nucleatum and Enterobacter species have been found in African American (AA) compared to Caucasian American (CA) CRC patients. Also, AA patients had decreased microbial diversity compared to CA patients. Periodontal-associated bacteria, Fusobacterium, Prevotella, Bacteroides and Porphyromonas, have been found in CRC tissues and in feces of CRC patients.
