Zheng-Yun Liang, Department of General Surgery, Qianxinan People’s Hospital, Xingyi 562400, Guizhou Province, China
Xing Kang, Hong Chen, Meng Wang, Wen-Xian Guan, Department of General Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing 210000, Jiangsu Province, China
Author contributions: Liang ZY and Kang X are equally contributed to this paper; Liang ZY contributed to the in vitro studies and drafted the manuscript; Kang X carried out the animal model studies and drafted the manuscript; Chen H participated the confocal and Western blot studies; Wang M contributed to the study design, coordination, data statistical analysis and made revisions; Guan WX contributed to the conceptions and design; all authors read and approved the final manuscript.
Supported by The National Natural Science Foundation of China, No. 81300268.
Institutional review board statement: This manuscript doesn’t involve any human participants, human data and human tissue in the study.
Institutional animal care and use committee statement: All aspects of the animal study were approved by the Animal Use and Care Committee of Nanjing Drum Tower hospital (Nanjing, China).
Conflict-of-interest statement: To the best of our knowledge, no conflict of interest exists.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at wangmeng001@263.net.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Wen-Xian Guan, MD, PhD, Department of General Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing Drum Tower Hospital, Nanjing 210000, Jiangsu Province, China. guan-wx@163.com
Telephone: +86-25-68182097 Fax: +86-25-68182097
Received: July 20, 2016
Peer-review started: July 21, 2016
First decision: September 13, 2016
Revised: December 11, 2016
Accepted: January 16, 2017
Article in press: January 18, 2017
Published online: April 15, 2017
