Scientometrics
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Mar 15, 2024; 16(3): 1059-1075
Published online Mar 15, 2024. doi: 10.4251/wjgo.v16.i3.1059
Insights into the history and tendency of glycosylation and digestive system tumor: A bibliometric-based visual analysis
Jie Jiang, Zai Luo, Ren-Chao Zhang, Yue-Ling Wang, Jun Zhang, Ming-Yu Duan, Zheng-Jun Qiu, Chen Huang
Jie Jiang, Zai Luo, Ren-Chao Zhang, Jun Zhang, Zheng-Jun Qiu, Chen Huang, Department of Gastrointestinal Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
Yue-Ling Wang, Jiangnan University Wuxi School of Medicine, Wuxi 214122, Jiangsu Province, China
Ming-Yu Duan, Department of Education, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
Co-first authors: Jie Jiang and Zai Luo.
Co-corresponding authors: Zheng-Jun Qiu and Chen Huang.
Author contributions: Huang C and Qiu ZJ designed the experiments, they have equal contributions; Jiang J and Luo Z searched articles, extracted data and wrote this manuscript; Jiang J, Luo Z, Zhang RC and Wang YL examined the original study data; Duan MY, Zhang J made the visualized analysis; Qiu ZJ, Huang C and Luo Z reviewed and revised the manuscript; all authors read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 82072662; Shanghai Municipal Education Commission - Gaofeng Clinical Medicine Grant Support, No. 2019142; Shanghai Three-year Action Plan to Promote Clinical Skills and Clinical Innovation in Municipal Hospitals, No. SHDC2020CR4022; and the 2021 Shanghai “Rising Stars of Medical Talent” Youth Development Program: Outstanding Youth Medical Talents.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chen Huang, MD, PhD, Chief Doctor, Director, Surgeon, Department of Gastrointestinal Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai 200080, China. Huangchen0204@sjtu.edu.cn
Received: November 20, 2023
Peer-review started: November 20, 2023
First decision: December 15, 2023
Revised: January 18, 2024
Accepted: January 25, 2024
Article in press: January 25, 2024
Published online: March 15, 2024
Abstract
BACKGROUND

Glycosylation, a commonly occurring post-translational modification, is highly expressed in several tumors, specifically in those of the digestive system, and plays a role in various cellular pathophysiological mechanisms. Although the importance and detection methods of glycosylation in digestive system tumors have garnered increasing attention in recent years, bibliometric analysis of this field remains scarce. The present study aims to identify the developmental trends and research hotspots of glycosylation in digestive system tumors.

AIM

To find and identify the developmental trends and research hotspots of glycosylation in digestive system tumors.

METHODS

We obtained relevant literature from the Web of Science Core Collection and employed VOSviewer 1.6.19 and CiteSpace (version 6.1.R6) to perform bibliometric analysis.

RESULTS

A total of 2042 documents spanning from 1978 to the present were analyzed, with the research process divided into three phases: the period of obscurity (1978-1990), continuous development period (1991-2006), and the rapid outbreak period (2007-2023). These documents were authored by researchers from 66 countries or regions, with the United States and China leading in terms of publication output. Reis Celso A had the highest number of publications, while Pinho SS was the most cited author. Co-occurrence analysis revealed the most popular keywords in this field are glycosylation, expression, cancer, colorectal cancer, and pancreatic cancer. Furthermore, the Journal of Proteome Research was the most prolific journal in terms of publications, while the Journal of Biological Chemistry had the most citations.

CONCLUSION

The bibliometric analysis shows current research focus is primarily on basic research in this field. However, future research should aim to utilize glycosylation as a target for treating tumor patients.

Keywords: Glycosylation, Cancer, Digestive system, Bibliometric analysis, CiteSpace, VOS viewer

Core Tip: Glycosylation assumes a progressively pivotal role within the contemporary landscape of cancer research, necessitating a quantitative exploration of extant scholarly contributions on glycation. This study curated a corpus of 2042 documents, employing Citespace and VOSviewer to depict the evolutionary trajectory of glycosylation research. We have comprehensively analyzed the current research status of glycosylation in the digestive system from the perspectives of authors, countries, journals, citations and etc. Our analysis reveals a predominant concentration of current glycation investigations in foundational domains. however, a discernible trajectory points towards its emergence as a prospective frontier in the realms of cancer diagnosis and therapeutic intervention.