Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Feb 15, 2024; 16(2): 354-363
Published online Feb 15, 2024. doi: 10.4251/wjgo.v16.i2.354
Effect of screening colonoscopy frequency on colorectal cancer mortality in patients with a family history of colorectal cancer
Li Zheng, Bin Li, Ling Lei, Li-Jia Wang, Zhi-Ping Zeng, Jian-Dong Yang
Li Zheng, Bin Li, Ling Lei, Li-Jia Wang, Zhi-Ping Zeng, Department of Gastroenterology, The First Hospital of Nanchang, Nanchang 330008, Jiangxi Province, China
Jian-Dong Yang, Department of General Surgery, The First Hospital of Nanchang, Nanchang 330008, Jiangxi Province, China
Author contributions: Zheng L and Yang JD contributed equally to this work; Zheng L, Li B, Lei L, Wang LJ, Zeng ZP, and Yang JD designed the study and were involved in the data acquisition and writing of this article; Zheng L and Yang JD contributed to the analysis of the manuscript; and all authors have read and approved the final manuscript.
Supported by Science and Technology Plan of Jiangxi Provincial Health Commission, No. 202311202 and No. SKJP220219076; and the Science and Technology Support Plan Project of Nanchang, Jiangxi Province, No. 2020-133-5.
Institutional review board statement: The study was reviewed and approved by the First Hospital of Nanchang Institutional Review Board.
Informed consent statement: All patients provided written informed consent for participation in the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian-Dong Yang, Doctor, Occupational Physician, Department of General Surgery, The First Hospital of Nanchang, No. 128 Xiangshan North Road, Nanchang 330008, Jiangxi Province, China. yjd-009@163.com
Received: October 23, 2023
Peer-review started: October 23, 2023
First decision: November 8, 2023
Revised: November 13, 2023
Accepted: December 11, 2023
Article in press: December 11, 2023
Published online: February 15, 2024
Abstract
BACKGROUND

Colorectal cancer is a common malignant tumor in China, and its incidence in the elderly is increasing annually. Inflammatory bowel disease is a group of chronic non-specific intestinal inflammatory diseases, including ulcerative colitis and Crohn’s disease.

AIM

To assess the effect of screening colonoscopy frequency on colorectal cancer mortality.

METHODS

We included the clinicopathological and follow-up data of patients with colorectal cancer who underwent laparoscopic colectomy or open colectomy at our Gastrointestinal Department between January 2019 and December 2022. Surgical indicators, oncological indicators, and survival rates were compared between the groups. The results of 104 patients who met the above criteria were extracted from the database (laparoscopic colectomy group = 63, open colectomy group = 41), and there were no statistically significant differences in the baseline data or follow-up time between the two groups.

RESULTS

Intraoperative blood loss, time to first ambulation, and time to first fluid intake were significantly lower in the laparoscopic colectomy group than in the open colectomy group. The differences in overall mortality, tumor-related mortality, and recurrence rates between the two groups were not statistically significant, and survival analysis showed that the differences in the cumulative overall survival, tumor-related survival, and cumulative recurrence-free rates between the two groups were not statistically significant.

CONCLUSION

In elderly patients with colorectal cancer, laparoscopic colectomy has better short-term outcomes than open colectomy, and laparoscopic colectomy has superior long-term survival outcomes compared with open colectomy.

Keywords: Colorectal cancer, Laparoscopic surgery, Open surgery, Prognosis, Laparoscopic colectomy, Open colectomy

Core Tip: Screening colonoscopy performed at different time frequencies did not show a statistically significant effect on overall mortality, tumor-related mortality, and recurrence rates in colorectal cancer patients with a family history of rectal cancer. However, laparoscopic surgery demonstrated better short-term outcomes compared to open surgery, while maintaining comparable long-term survival results. This suggests that laparoscopic surgery may be a favorable option for elderly patients with colorectal cancer.