Batista DMO, da Silva JMC, Gigek CO, Smith MAC, de Assumpção PP, Calcagno DQ. Metastasis-associated lung adenocarcinoma transcript 1 molecular mechanisms in gastric cancer progression. World J Gastrointest Oncol 2023; 15(9): 1520-1530 [PMID: 37746646 DOI: 10.4251/wjgo.v15.i9.1520]
Corresponding Author of This Article
Danielle Queiroz Calcagno, PhD, Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, R. dos Mundurucus, 4487-Guamá, Belém-PA, Belém 66073-000, Pará, Brazil. danicalcagno@gmail.com
Research Domain of This Article
Biochemistry & Molecular Biology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Sep 15, 2023; 15(9): 1520-1530 Published online Sep 15, 2023. doi: 10.4251/wjgo.v15.i9.1520
Metastasis-associated lung adenocarcinoma transcript 1 molecular mechanisms in gastric cancer progression
Daniel Mateus de Oliveira Batista, Jéssica Manoelli Costa da Silva, Carolina de Oliveira Gigek, Marília de Arruda Cardoso Smith, Paulo Pimentel de Assumpção, Danielle Queiroz Calcagno
Daniel Mateus de Oliveira Batista, Jéssica Manoelli Costa da Silva, Paulo Pimentel de Assumpção, Danielle Queiroz Calcagno, Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém 66073-000, Pará, Brazil
Carolina de Oliveira Gigek, Departamento de Patologia, Universidade Federal de São Paulo, São Paulo 04023-062, São Paulo, Brazil
Marília de Arruda Cardoso Smith, Disciplina de Genética,Departamento de Morfologia e Genética, Universidade Federal de São Paulo, São Paulo 04023-900, São Paulo, Brazil
Author contributions: Batista DMO, da Silva JMC, Calcagno DQ wrote the paper; Batista DMO designed the tables and the figures; Smith MAC, Gigek CO, and de Assumpção PP critically revised this paper; Calcagno DQ designed the article.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Danielle Queiroz Calcagno, PhD, Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, R. dos Mundurucus, 4487-Guamá, Belém-PA, Belém 66073-000, Pará, Brazil. danicalcagno@gmail.com
Received: May 2, 2023 Peer-review started: May 2, 2023 First decision: May 9, 2023 Revised: May 30, 2023 Accepted: July 27, 2023 Article in press: July 27, 2023 Published online: September 15, 2023
Abstract
Gastric cancer (GC) remains among the most common cancers worldwide with a high mortality-to-incidence ratio. Accumulated evidence suggests that long noncoding RNAs (lncRNAs) are involved in gastric carcinogenesis. These transcripts are longer than 200 nucleotides and modulate gene expression at multiple molecular levels, inducing or inhibiting biological processes and diseases. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is one of the best-studied lncRNAs with comprehensive actions contributing to cancer progression. This lncRNA regulates gene expression at the transcriptional and posttranscriptional levels through interactions with microRNAs and proteins. In the present review, we discussed the molecular mechanism of MALAT1 and summarized the current knowledge of its expression in GC. Moreover, we highlighted the potential use of MALAT1 as a biomarker, including liquid biopsy.
Core Tip: Gastric cancer (GC) is one of the leading causes of cancer-related deaths globally, highlighting the need for novel biomarker for improved evaluation. The long noncoding RNAs metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) plays a crucial role in many cellular processes associated with GC progression, including proliferation, invasion, metastasis, and drug response. The current review summarizes the present knowledge of MALAT1 in GC, elucidating its molecular mechanisms of action and potential as a biomarker for the clinical management of GC.
