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World J Gastrointest Oncol. Aug 15, 2021; 13(8): 822-834
Published online Aug 15, 2021. doi: 10.4251/wjgo.v13.i8.822
Reflectance spectra analysis for mucous assessment
Toru Chiba, Masaharu Murata, Takahito Kawano, Makoto Hashizume, Tomohiko Akahoshi
Toru Chiba, Pentax_LifeCare, HOYA Corporation, Akishima-shi 196-0012, Tokyo, Japan
Masaharu Murata, Takahito Kawano, Makoto Hashizume, Center for Advanced Medical Innovation, Kyushu University, Fukuoka-shi 812-8582, Fukuoka, Japan
Tomohiko Akahoshi, Department of Disaster and Emergency Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka_shi 812-8582, Fukuoka, Japan
Author contributions: Chiba T, Murata M, Akahoshi T, and Hashizume M conceived the paper; Murata M and Chiba T designed and co-ordinated the writing; Chiba T performed statistical analysis.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Toru Chiba, BSc, Associate Specialist, Pentax_LifeCare, HOYA Corporation, Pentax Life Care Division Showanomori Technology Center 1-1-110 Tsutsujigaoka, Akishima-shi 196-0012, Tokyo, Japan. toru.chiba@pentaxmedical.com
Received: March 1, 2021
Peer-review started: March 1, 2021
First decision: April 19, 2021
Revised: April 26, 2021
Accepted: July 9, 2021
Article in press: July 9, 2021
Published online: August 15, 2021
Abstract

This review report represents an overview of research and development on medical hyperspectral imaging technology and its applications. Spectral imaging technology is attracting attention as a new imaging modality for medical applications, especially in disease diagnosis and image-guided surgery. Considering the recent advances in imaging, this technology provides an opportunity for two-dimensional mapping of oxygen saturation (SatO2) of blood with high accuracy, spatial spectral imaging, and its analysis and provides detection and diagnostic information about the tissue physiology and morphology. Multispectral imaging also provides information about tissue oxygenation, perfusion, and potential function during surgery. Analytical algorithm has been examined, and indication of accurate map of relative hemoglobin concentration and SatO2 can be indicated with preferable resolution and frame rate. This technology is expected to provide promising biomedical information in practical use. Several studies suggested that blood flow and SatO2 are associated with gastrointestinal disorders, particularly malignant tumor conditions. The use and analysis of spectroscopic images are expected to potentially play a role in the detection and diagnosis of these diseases.

Keywords: Diffuse reflectance spectroscopy, Endoscopy, Hemoglobin saturation, Hypoxia, Gastrointestinal cancer, Tumor

Core Tip: Hemoglobin saturation relative hemoglobin concentration diffuse reflectance spectroscopic. The use of spectroscopic information for pathological diagnosis and detection has been studied. Detailed analysis of this information will contribute to the development of novel objective diagnostic techniques for diseases. In the latest research, it has become possible to visualize pathological conditions by indicating the two-dimensional distribution of blood concentration and oxygen saturation in real time, which can be realized without dosage. In the near future, derived research field that can be greatly expected to develop into future prediction of pathological conditions when performed in combination with statistical methods.