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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Mar 16, 2023; 15(3): 153-162
Published online Mar 16, 2023. doi: 10.4253/wjge.v15.i3.153
Published online Mar 16, 2023. doi: 10.4253/wjge.v15.i3.153
Aluminum phosphate gel reduces early rebleeding in cirrhotic patients with gastric variceal bleeding treated with histoacryl injection therapy
Hao-Tian Zeng, Zhu-Liang Zhang, Xi-Min Lin, Min-Si Peng, Department of Gastroenterology, The Second Clinical Medical College, Jinan University, Shenzhen 518000, Guangdong Province, China
Li-Sheng Wang, Zheng-Lei Xu, Department of Gastroenterology, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, Shenzhen 518000, Guangdong Province, China
Author contributions: Xu ZL conceived the idea for the manuscript; Zeng HT and Zhang ZL contributed equally to this study, are considered as co-first authors, and wrote the first draft of the manuscript; Lin XM and Peng MS searched part of the information; Wang LS reviewed and revised the manuscript.
Supported by Clinical Research and Cultivation Project of Shenzhen People's Hospital , No. SYLCYJ202116 .
Institutional review board statement: The study was reviewed and approved by the Medical Ethics Committee of Shenzhen Municipal People's Hospital Institutional Review Board (Approval No. 20150108).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There is no any conflict-of-interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zheng-Lei Xu, MD, Chief Doctor, Department of Gastroenterology, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, No. 1017 Dongmen North Road, Shenzhen 518000, Guangdong Province, China. 78249073@qq.com
Received: November 9, 2022
Peer-review started: November 9, 2022
First decision: November 22, 2022
Revised: November 26, 2022
Accepted: March 1, 2023
Article in press: March 1, 2023
Published online: March 16, 2023
Peer-review started: November 9, 2022
First decision: November 22, 2022
Revised: November 26, 2022
Accepted: March 1, 2023
Article in press: March 1, 2023
Published online: March 16, 2023
Core Tip
Core Tip: Gastric varices bleeding (GVB) is a serious life-threatening disease, and endoscopic variceal histoacryl injection therapy (EVHT) can effectively maintain hemostasis during the disease. Nevertheless, complications after EVHT, such as bleeding during drainage and ulceration at the injection site, can lead to early rebleeding. Currently, there are few clinical studies on preventing early rebleeding after EVHT in patients with GVB. We have found that using aluminium phosphate gel combined with proton pump inhibitor after EVHT could significantly reduce early rebleeding after endoscopic treatment in individuals with GVB.