Published online Mar 16, 2023. doi: 10.4253/wjge.v15.i3.153
Peer-review started: November 9, 2022
First decision: November 22, 2022
Revised: November 26, 2022
Accepted: March 1, 2023
Article in press: March 1, 2023
Published online: March 16, 2023
The incidence of early rebleeding after endoscopic variceal histoacryl injection therapy (EVHT) of varicose veins in the fundus of the stomach is high, which may lead to serious consequences. It is very important to reduce the incidence of early rebleeding.
Reducing the incidence of early rebleeding after EVHT treatment reduces the risk of patients and may extend their life expectancy. Proton pump inhibitor (PPI) treatment has been found to reduce the incidence of early rebleeding. Aluminium phosphate gel (APG) can promote the healing of gastric ulcers. Can the combination of APG and PPI further reduce the incidence of early rebleeding?
This study aimed to verify whether the combination of APG and PPI can reduce the incidence of early rebleeding after EVHT.
We randomly divided patients after EVHT into two groups. One group was treated on PPI after EVHT, and the other group took PPI in combination with APG. We statistically analyzed the data of both groups and observed the early rebleeding rates in both groups.
The early rebleeding rate in PPI + APG group was 3.16% (3/95), which was much lower than that in the PPI group (12.87%, 13/101). Causes of early rebleeding: The incidence of gastric ulcer bleeding in the PPI + APG group was 2.11% (2/95), which was reduced in comparison to that in the PPI group (11.88%, 12/101); the incidence of venous bleeding in PPI + APG group and PPI group was 1.05% (1/95) and 0.99% (1/101), respectively, and there was no significant difference between them. The incidence of abdominal pain in the PPI + APG group was 3.16% (3/95), which was lower than that in the PPI group (11.88%, 12/101).
PPI combined with APG can significantly reduce the incidence of early rebleeding and postoperative abdominal pain in cirrhotic patients with GVB after taking EVHT.
The combination of APG with PPI can reduce the bleeding incidence of gastric ulcers after EVHT.