Clinical Trials Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Jan 16, 2020; 12(1): 23-32
Published online Jan 16, 2020. doi: 10.4253/wjge.v12.i1.23
High-definition optical magnification with digital chromoendoscopy detects gastric mucosal changes in dyspeptic-patients
Carlos Robles-Medranda, Manuel Valero, Miguel Puga-Tejada, Roberto Oleas, Jorge Baquerizo-Burgos, Miguel Soria-Alcívar, Haydee Alvarado-Escobar, Hannah Pitanga-Lukashok
Carlos Robles-Medranda, Manuel Valero, Miguel Puga-Tejada, Roberto Oleas, Jorge Baquerizo-Burgos, Miguel Soria-Alcívar, Haydee Alvarado-Escobar, Hannah Pitanga-Lukashok, Gastroenterology and Endoscopy Division, Instituto Ecuatoriano de Enfermedades Digestivas (IECED), Guayaquil 090505, Ecuador
Author contributions: Robles-Medranda C and Pitanga-Lukashok H designed the study; Robles-Medranda C, Valero M, Soria-Alcívar M and Alvarado-Escobar H performed the research; Puga-Tejada M analyzed the data; Valero M, Oleas R and Baquerizo-Burgos J wrote the paper.
Institutional review board statement: This study was reviewed and approved by the Instituto Ecuatoriano de Enfermedades Digestivas Institutional Review Board.
Clinical trial registration statement: This study is registered on clinical trials.gov under the code NCT02597517.
Informed consent statement: Informed written consent was provided from all study participants or their legal guardian prior to study enrollment.
Conflict-of-interest statement: Robles-Medranda C is a key opinion leader for Pentax Medial and Boston Scientific. The other authors declare that they have no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Carlos Robles-Medranda, MD, Professor, Gastroenterology and Endoscopy Division, Instituto Ecuatoriano de Enfermedades Digestivas (IECED), Av. Abel Romeo Castillo y Av. Juan Tanca Marengo, Torre Vitalis, Mezzanine 3, Guayaquil 090505, Ecuador. carlosoakm@yahoo.es
Received: June 28, 2019
Peer-review started: June 29, 2019
First decision: August 2, 2019
Revised: August 13, 2019
Accepted: November 18, 2019
Article in press: November 18, 2019
Published online: January 16, 2020
Core Tip

Core tip: The accurate and reliable detection of Helicobacter pylori-associated gastritis and gastric atrophy is imperative for appropriate therapy, preventing the development of gastric neoplasia. Digital chromoendoscopy with optical magnification improved the identification of mucosal superficial and vascular patterns in the gastric mucosa of dyspeptic patients. We described a high sensitivity and accuracy for predicting normal gastric mucosa and Helicobacter pylori-associated gastritis, with a high interobserver agreement. The accurate detection of gastric infection by Helicobacter pylori and the presence of premalignant lesion at an early stage are important for the effective provision of treatment.