Cockcroft-Gault revisited: New de-liver-ance on recommendations for use in cirrhosis

Figure 2 Systemic effects of cirrhosis. Increased portal vein pressure results in vasodilation decreasing peripheral vascular resistance (PVR) and effective arterial blood volume (EABV). To compensate for this, increased renin-angiotensin-aldosterone (RAA) activation leads to sodium and fluid retention along with renal vasoconstriction and reduced glomerular filtration rate. Adopted with permission from Ho et al[27]. HE: Hepatic encephalopathy.