Impact of comorbidity on waiting list and post-transplant outcomes in patients undergoing liver retransplantation

Table 3 Univariate and multivariate analysis of factors associated with 1-year post-transplant patient and graft survival of retransplanted patients on Cox proportional hazard analysis

Variable	Patient survival			Graft survival
	HR	95%CI	P value	HR	95%CI	P value
Univariate analysis
Age	0.796	0.973-1.021	0.997	0.992	0.969-1.016	0.515
Early graft dysfunction	2.143	0.919-4.998	0.078	1.788	0.776-4.123	0.173
DM	2.242	0.961-5.228	0.062	2.004	0.869-4.618	0.103
Renal impairment	4.385	2.133-9.017	< 0.001	3.494	1.759-6.941	< 0.001
CCI continuous	3.344	1.949-5.738	< 0.001	2.755	1.638-4.633	< 0.001
CCI dichotomous	3.56	1.691-7.493	0.001	2.751	1.377-5.494	0.004
Pre-LRT mechanical ventilation	3.044	1.461-6.342	0.003	2.456	1.210-4.983	0.013
Pre-LRT vasopressor support	4.714	2.239-9.928	< 0.001	3.618	1.758-7.443	< 0.001
Pre-LRT renal replacement therapy	4.233	2.029-8.829	< 0.001	3.271	1.630-6.562	0.001
Transplant from ICU	2.744	1.318-5.712	0.007	2.101	1.049-4.206	0.036
MELD score ≥ 18	4.714	2.239-9.928	0.009	3.105	1.399-6.890	0.005
Encephalopathy at LRT	2.593	1.213-5.544	0.014	2.28	1.121-4.639	0.023
Hb, g/dL	0.791	0.629-0.994	0.044	0.792	0.636-0.985	0.037
ABO mismatch	2.37	1.015-5.532	0.046	2.338	1.053-5.190	0.037
Cold ischemia time (h)	1.113	0.987-1.255	0.082	1.081	0.962-1.216	0.191
DRI	0.68	0.236-1.963	0.476	0.693	0.250-1.918	0.476
DRI > 1.8	1.736	0.772-3.902	0.180	1.67	0.747-3.737	0.212
Multivariate analysis
Renal impairment	3.215	1.147-12.603	0.005	2.543	1.160-5.573	0.020
CCI Continuous	2.823	1.563-5.101	0.001	2.350	1.331-4.148	0.003
CCI Dichotomous	2.87	1.306-6.307	0.009	2.223	1.067-4.633	0.033
Pre-LRT mechanical ventilation	2.52	1.126-5.637	0.024	2.099	0.968-4.552	0.060
Pre-LRT vasopressor support	4.004	1.554-10.314	0.004	3.023	1.216-7.514	0.017
Pre-LRT renal replacement therapy	2.691	1.261-5.740	0.01	2.441	1.107-5.383	0.027
Transplant from ICU	1.859	0.794-4.354	0.153	1.437	0.640-3.230	0.380
MELD score ≥ 18	2.506	1.044-6.018	0.04	2.512	1.098-5.743	0.029
Encephalopathy at LRT	1.922	0.856-4.315	0.113	1.626	0.752-3.515	0.217
Hb, g/dL at LRT	0.883	0.694-1.125	0.314	0.883	0.698-1.116	0.297
ABO mismatch	1.795	0.739-4363	0.197	1.827	0.791-4.220	0.158

DM: Diabetes mellitus; LRT: Liver retransplant; ICU: Intensive care unit; CCI: Charlson comorbidity index; Hb: Haemoglobin; INR: International normalised ratio; MELD: Model for end-stage liver disease; DRI: Donor risk index.