Impact of comorbidity on waiting list and post-transplant outcomes in patients undergoing liver retransplantation

Table 2 Factors associated with waiting list mortality in liver retransplantation patients on univariate and multivariate Cox proportional hazard analysis

Variable	Univariate			Multivariate
	HR	95%CI	P value	HR	95%CI	P value
Age > 60 yr	2.959	0.550-3.896	0.048	3.102	1.015-9.484	0.047
DM	1.587	0.499-5.042	0.434
Renal impairment	4.771	1.496-15.217	0.008	3.802	1.147-12.603	0.029
CCI continuous	3.121	1.589-6.130	0.001	2.688	1.222-5.912	0.014
CCI dichotomous	6.528	1.472-28.962	0.014	5.475	1.177-25.464	0.030
Hb, g/dL	0.755	0.545-1.047	0.092
Platelet count, × 109/mL	0.994	0.986-1.001	0.090
Bilirubin, mg/dL	1.012	0.979-1.045	0.481
Creatinine, mg/dL	3.200	1.888-5.421	< 0.001	2.691	1.261-5.740	0.010
INR	1.489	1.055-2.102	0.024	1.406	0.967-2.044	0.075
Encephalopathy	2.049	0.620-6.770	0.239
Ascites	2.781	1.006-7.682	0.049
MELD	1.154	1.067-1.248	< 0.001	2.691	1.261-5.740	0.01
MELD ≥ 18	3.827	1.190-12.315	0.024	4.369	1.255-15.215	0.021
Na, mmol/L	0.945	0.870-1.027	0.180
UKELD	1.121	1.029-1.220	0.009	1.117	1.037-1.204	0.003

DM: Diabetes mellitus; CCI: Charlson comorbidity index; Hb: Haemoglobin; INR: International normalised ratio; MELD: Model for end-stage liver disease; Na: Serum sodium; UKELD: United Kingdom end-stage liver disease model.