Therapeutic alternatives for the treatment of type 1 hepatorenal syndrome: A Delphi technique-based consensus

Table 2 Levels of evidence according to the study design

Level of evidence	Description
Type I	Evidence obtained at least from one well-designed, randomized, controlled1 trial or from a systematic review of randomized clinical studies
Type II	II-1 evidence obtained from non-randomized, prospective, controlled1 studies
	II-2 evidence obtained from cohort observational studies2 or case-control studies, preferably multi-centric
	II-3 evidence obtained from case series
Type III	Opinion of authorities on the subject matter based on expertise, expert committees, case reports, pathophysiological studies or basic science studies

¹A controlled study is a study where the intervention is managed by the researcher;

²An observational study is a study where the intervention is not controlled by the researcher.